Definition
Nephrogenic diabetes insipidus is a disease characterized by the production of excessively dilute urine due to the kidneys' failure to respond to antidiuretic hormone (ADH).
Symptoms
- Excessive urination (polyuria)
- Excessive thirst (polydipsia)
- Dehydration
- Fever (in infants)
Reasons
Hereditary (V2 receptor mutation) or acquired (lithium use, hypercalcemia, hypokalemia).
Diagnosis
Inability to concentrate urine on water deprivation test, high plasma osmolarity.
Treatment
Adequate fluid intake, thiazide diuretics, low salt and protein diet.
Which Polyclinic Should You Apply To?
Nephrology Polyclinic
What to Do in an Emergency?
In case of severe dehydration and hypernatremia, emergency services should be consulted.
This page is for general information purposes only.