Definition
Liddle syndrome is a rare autosomal dominant disease characterized by hypertension and low renin/aldosterone, resulting from overactivity of the epithelial sodium channel (ENaC) in the distal nephron.
Symptoms
- Severe hypertension (at a young age)
- low blood potassium
- Metabolic alkalosis
- Headache
Reasons
Gain-of-function mutations in genes encoding the beta or gamma subunit of the ENaC channel.
Diagnosis
Low renin and aldosterone in the blood, hypokalemia, genetic testing.
Treatment
ENaC channel blockers (amiloride, triamterene), salt restriction.
Which Polyclinic Should You Apply To?
Nephrology Polyclinic or Endocrinology Polyclinic
What to Do in an Emergency?
In case of hypertensive crisis, emergency services should be consulted.
This page is for general information purposes only.