Definition
Donohue syndrome is a severe autosomal recessive disorder characterized by extreme insulin resistance, growth retardation, characteristic facial appearance, and endocrine disorders.
Symptoms
- Severe growth retardation
- Inelastic skin
- Hypertrichosis (excessive hair growth)
- Wide nose, large ears
Reasons
Insulin receptor gene (INSR) mutations.
Diagnosis
Clinical findings, high insulin levels, genetic testing.
Treatment
Symptomatic treatment, nutritional support, growth factors.
Which Polyclinic Should You Apply To?
Pediatric Endocrinology Polyclinic
What to Do in an Emergency?
In case of severe hypoglycemia or metabolic acidosis, emergency services should be consulted.
This page is for general information purposes only.