{"id":21543,"date":"2025-11-17T04:06:05","date_gmt":"2025-11-17T01:06:05","guid":{"rendered":"https:\/\/hastane.ksu.edu.tr\/hastaliklar\/paroksismal-nokturnal-hemoglobinuri\/"},"modified":"2025-11-17T04:06:05","modified_gmt":"2025-11-17T01:06:05","slug":"paroksismal-nokturnal-hemoglobinuri","status":"publish","type":"hastaliklar","link":"https:\/\/hastane.ksu.edu.tr\/en\/hastaliklar\/paroksismal-nokturnal-hemoglobinuri\/","title":{"rendered":"Paroxysmal Nocturnal Hemoglobinuria"},"content":{"rendered":"<h2>Definition<\/h2>\n<p>Paroxysmal nocturnal hemoglobinuria is a rare disease characterized by complement-mediated hemolysis due to PIG-A gene mutation.<\/p>\n<h2>Symptoms<\/h2>\n<ul>\n<li>Dark urine<\/li>\n<li>Weakness<\/li>\n<li>Stomach ache<\/li>\n<li>Headache<\/li>\n<\/ul>\n<h2>Reasons<\/h2>\n<p>PIG-A gene mutation.<\/p>\n<h2>Diagnosis<\/h2>\n<p>Flow cytometry, LDH, haptoglobin.<\/p>\n<h2>Treatment<\/h2>\n<p>Eculizumab, corticosteroids, stem cell transplantation.<\/p>\n<h2>Which Polyclinic Should You Apply To?<\/h2>\n<p><strong>Hematology Polyclinic<\/strong><\/p>\n<h2>What to Do in an Emergency?<\/h2>\n<p>In case of severe hemolysis, emergency services should be consulted.<\/p>\n<p><em>This page is for general information purposes only.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Definition Paroxysmal nocturnal hemoglobinuria is a rare disease characterized by complement-mediated hemolysis due to a PIG-A gene mutation. Symptoms Dark urine Weakness Abdominal pain Headache Causes PIG-A gene mutation. Diagnosis Flow cytometry, LDH, haptoglobin. Treatment Eculizumab, corticosteroids, stem cell transplantation. Which Clinic Should You Go To? Hematology Clinic What to Do in an Emergency? In case of severe hemolysis, go to the emergency room. This [\u2026]<\/p>","protected":false},"author":1,"featured_media":0,"menu_order":0,"template":"","format":"standard","meta":{"_acf_changed":false,"slim_seo":{"title":"Paroxysmal Nocturnal Hemoglobinuria - Kahramanmara\u015f S\u00fct\u00e7\u00fc \u0130mam University Health Practice and Research Hospital","description":"Definition: Paroxysmal nocturnal hemoglobinuria is a rare disease characterized by complement-mediated hemolysis due to a PIG-A gene mutation. Symptoms: Dark urine"},"footnotes":""},"class_list":["post-21543","hastaliklar","type-hastaliklar","status-publish","format-standard","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/hastaliklar\/21543","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/hastaliklar"}],"about":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/types\/hastaliklar"}],"author":[{"embeddable":true,"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":0,"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/hastaliklar\/21543\/revisions"}],"wp:attachment":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/media?parent=21543"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}