{"id":21345,"date":"2025-11-17T01:45:46","date_gmt":"2025-11-16T22:45:46","guid":{"rendered":"https:\/\/hastane.ksu.edu.tr\/hastaliklar\/donohue-sendromu\/"},"modified":"2025-11-17T01:45:46","modified_gmt":"2025-11-16T22:45:46","slug":"donohue-sendromu","status":"publish","type":"hastaliklar","link":"https:\/\/hastane.ksu.edu.tr\/en\/hastaliklar\/donohue-sendromu\/","title":{"rendered":"Donohue Syndrome (Leprechaunism)"},"content":{"rendered":"<h2>Definition<\/h2>\n<p>Donohue syndrome is a severe autosomal recessive disorder characterized by extreme insulin resistance, growth retardation, characteristic facial appearance, and endocrine disorders.<\/p>\n<h2>Symptoms<\/h2>\n<ul>\n<li>Severe growth retardation<\/li>\n<li>Inelastic skin<\/li>\n<li>Hypertrichosis (excessive hair growth)<\/li>\n<li>Wide nose, large ears<\/li>\n<\/ul>\n<h2>Reasons<\/h2>\n<p>Insulin receptor gene (INSR) mutations.<\/p>\n<h2>Diagnosis<\/h2>\n<p>Clinical findings, high insulin levels, genetic testing.<\/p>\n<h2>Treatment<\/h2>\n<p>Symptomatic treatment, nutritional support, growth factors.<\/p>\n<h2>Which Polyclinic Should You Apply To?<\/h2>\n<p><strong>Pediatric Endocrinology Polyclinic<\/strong><\/p>\n<h2>What to Do in an Emergency?<\/h2>\n<p>In case of severe hypoglycemia or metabolic acidosis, emergency services should be consulted.<\/p>\n<p><em>This page is for general information purposes only.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Definition Donohue syndrome is a severe autosomal recessive disorder characterized by excessive insulin resistance, growth retardation, a characteristic facial appearance, and endocrine disorders. Symptoms Severe growth retardation Inelastic skin Hypertrichosis (excessive hair growth) Wide nose, large ears Causes Mutations in the insulin receptor gene (INSR). Diagnosis Clinical findings, high insulin levels, genetic testing. Treatment Symptomatic treatment, nutritional support, [\u2026]<\/p>","protected":false},"author":1,"featured_media":0,"menu_order":0,"template":"","format":"standard","meta":{"_acf_changed":false,"slim_seo":{"title":"Donohue Syndrome (Leprechaunism) - Kahramanmara\u015f S\u00fct\u00e7\u00fc \u0130mam University Health Practice and Research Hospital","description":"Definition: Donohue syndrome is an autosomal recessive disorder characterized by excessive insulin resistance, growth retardation, characteristic facial features, and endocrine abnormalities."},"footnotes":""},"class_list":["post-21345","hastaliklar","type-hastaliklar","status-publish","format-standard","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/hastaliklar\/21345","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/hastaliklar"}],"about":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/types\/hastaliklar"}],"author":[{"embeddable":true,"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":0,"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/hastaliklar\/21345\/revisions"}],"wp:attachment":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/media?parent=21345"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}