{"id":21339,"date":"2025-11-17T01:45:45","date_gmt":"2025-11-16T22:45:45","guid":{"rendered":"https:\/\/hastane.ksu.edu.tr\/hastaliklar\/wolfram-sendromu\/"},"modified":"2025-11-17T01:45:45","modified_gmt":"2025-11-16T22:45:45","slug":"wolfram-sendromu","status":"publish","type":"hastaliklar","link":"https:\/\/hastane.ksu.edu.tr\/en\/hastaliklar\/wolfram-sendromu\/","title":{"rendered":"Wolfram Syndrome (DIDMOAD)"},"content":{"rendered":"<h2>Definition<\/h2>\n<p>Wolfram syndrome is a rare autosomal recessive neurodegenerative disease characterized by Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy and Hearing Loss (DIDMOAD).<\/p>\n<h2>Symptoms<\/h2>\n<ul>\n<li>Childhood-onset diabetes<\/li>\n<li>Optic atrophy (vision loss)<\/li>\n<li>Diabetes insipidus<\/li>\n<li>Sensorineural hearing loss<\/li>\n<\/ul>\n<h2>Reasons<\/h2>\n<p>Mutation in the WFS1 gene.<\/p>\n<h2>Diagnosis<\/h2>\n<p>Clinical criteria, genetic testing.<\/p>\n<h2>Treatment<\/h2>\n<p>Symptomatic treatment (insulin, desmopressin), supportive care.<\/p>\n<h2>Which Polyclinic Should You Apply To?<\/h2>\n<p><strong>Endocrinology Polyclinic<\/strong> or <strong>Neurology Polyclinic<\/strong><\/p>\n<h2>What to Do in an Emergency?<\/h2>\n<p>In case of diabetic ketoacidosis or severe dehydration, emergency services should be consulted.<\/p>\n<p><em>This page is for general information purposes only.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Definition Wolfram syndrome is a rare, autosomal recessive neurodegenerative disorder characterized by Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Hearing Loss (DIDMOAD). Symptoms Childhood-onset diabetes Optic atrophy (vision loss) Diabetes insipidus Sensorineural hearing loss Causes Mutation in the WFS1 gene. Diagnosis Clinical criteria, genetic testing. Treatment Symptomatic treatment (insulin, desmopressin), supportive care. Which Clinic to Consult? Endocrinology [\u2026]<\/p>","protected":false},"author":1,"featured_media":0,"menu_order":0,"template":"","format":"standard","meta":{"_acf_changed":false,"slim_seo":{"title":"Wolfram Syndrome (DIDMOAD) - Kahramanmara\u015f S\u00fct\u00e7\u00fc \u0130mam University Health Practice and Research Hospital","description":"Definition: Wolfram syndrome is a rare, autosomal recessive neurodegenerative disorder characterized by Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Hearing Loss (DIDMOAD)."},"footnotes":""},"class_list":["post-21339","hastaliklar","type-hastaliklar","status-publish","format-standard","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/hastaliklar\/21339","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/hastaliklar"}],"about":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/types\/hastaliklar"}],"author":[{"embeddable":true,"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":0,"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/hastaliklar\/21339\/revisions"}],"wp:attachment":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/media?parent=21339"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}