{"id":21336,"date":"2025-11-17T01:45:45","date_gmt":"2025-11-16T22:45:45","guid":{"rendered":"https:\/\/hastane.ksu.edu.tr\/hastaliklar\/kallmann-sendromu\/"},"modified":"2025-11-17T01:45:45","modified_gmt":"2025-11-16T22:45:45","slug":"kallmann-sendromu","status":"publish","type":"hastaliklar","link":"https:\/\/hastane.ksu.edu.tr\/en\/hastaliklar\/kallmann-sendromu\/","title":{"rendered":"Kallmann Syndrome"},"content":{"rendered":"<h2>Definition<\/h2>\n<p>Kallmann syndrome is a genetic disease due to gonadotropin-releasing hormone (GnRH) deficiency, characterized by hypogonadotropic hypogonadism and olfactory dysfunction (anosmia\/hyposmia).<\/p>\n<h2>Symptoms<\/h2>\n<ul>\n<li>Delayed puberty<\/li>\n<li>Infertility<\/li>\n<li>Inability to smell (anosmia)<\/li>\n<li>Other anomalies such as hearing loss and cleft palate<\/li>\n<\/ul>\n<h2>Reasons<\/h2>\n<p>Migration defect of GnRH neurons (mutation in genes such as KAL1, FGFR1, PROK2).<\/p>\n<h2>Diagnosis<\/h2>\n<p>Low gonadotropin and sex hormones, smell test, genetic analysis.<\/p>\n<h2>Treatment<\/h2>\n<p>Hormone replacement therapy (testosterone\/oestrogen), fertility treatment (GnRH pump or gonadotropins).<\/p>\n<h2>Which Polyclinic Should You Apply To?<\/h2>\n<p><strong>Endocrinology Polyclinic<\/strong><\/p>\n<h2>What to Do in an Emergency?<\/h2>\n<p>In case of acute psychological distress, emergency services should be consulted.<\/p>\n<p><em>This page is for general information purposes only.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Definition: Kallmann syndrome is a genetic disorder caused by gonadotropin-releasing hormone (GnRH) deficiency, characterized by hypogonadotropic hypogonadism and olfactory dysfunction (anosmia\/hyposmia). Symptoms: Delayed puberty, infertility, loss of smell (anosmia), hearing loss, and other anomalies such as cleft palate. Causes: Migration defect of GnRH neurons (mutations in genes such as KAL1, FGFR1, PROK2). Diagnosis: Low gonadotropin and sex hormone levels, olfactory test, genetic [\u2026]<\/p>","protected":false},"author":1,"featured_media":0,"menu_order":0,"template":"","format":"standard","meta":{"_acf_changed":false,"slim_seo":{"title":"Kallmann Syndrome - Kahramanmara\u015f S\u00fct\u00e7\u00fc \u0130mam University Health Practice and Research Hospital","description":"Definition: Kallmann syndrome is a gonadotropin-releasing hormone (GnRH) deficiency characterized by hypogonadotropic hypogonadism and olfactory dysfunction (anosmia\/hyposmia)."},"footnotes":""},"class_list":["post-21336","hastaliklar","type-hastaliklar","status-publish","format-standard","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/hastaliklar\/21336","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/hastaliklar"}],"about":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/types\/hastaliklar"}],"author":[{"embeddable":true,"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":0,"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/hastaliklar\/21336\/revisions"}],"wp:attachment":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/media?parent=21336"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}