{"id":21322,"date":"2025-11-17T01:45:45","date_gmt":"2025-11-16T22:45:45","guid":{"rendered":"https:\/\/hastane.ksu.edu.tr\/hastaliklar\/liddle-sendromu\/"},"modified":"2025-11-17T01:45:45","modified_gmt":"2025-11-16T22:45:45","slug":"liddle-sendromu","status":"publish","type":"hastaliklar","link":"https:\/\/hastane.ksu.edu.tr\/en\/hastaliklar\/liddle-sendromu\/","title":{"rendered":"Liddle Syndrome"},"content":{"rendered":"<h2>Definition<\/h2>\n<p>Liddle syndrome is a rare autosomal dominant disease characterized by hypertension and low renin\/aldosterone, resulting from overactivity of the epithelial sodium channel (ENaC) in the distal nephron.<\/p>\n<h2>Symptoms<\/h2>\n<ul>\n<li>Severe hypertension (at a young age)<\/li>\n<li>low blood potassium<\/li>\n<li>Metabolic alkalosis<\/li>\n<li>Headache<\/li>\n<\/ul>\n<h2>Reasons<\/h2>\n<p>Gain-of-function mutations in genes encoding the beta or gamma subunit of the ENaC channel.<\/p>\n<h2>Diagnosis<\/h2>\n<p>Low renin and aldosterone in the blood, hypokalemia, genetic testing.<\/p>\n<h2>Treatment<\/h2>\n<p>ENaC channel blockers (amiloride, triamterene), salt restriction.<\/p>\n<h2>Which Polyclinic Should You Apply To?<\/h2>\n<p><strong>Nephrology Polyclinic<\/strong> or <strong>Endocrinology Polyclinic<\/strong><\/p>\n<h2>What to Do in an Emergency?<\/h2>\n<p>In case of hypertensive crisis, emergency services should be consulted.<\/p>\n<p><em>This page is for general information purposes only.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Definition Liddle syndrome is a rare autosomal dominant disorder characterized by hypertension and low renin\/aldosterone levels resulting from overactivity of the epithelial sodium channel (ENaC) in the distal nephron. Symptoms Severe hypertension (at a young age) Low blood potassium Metabolic alkalosis Headache Causes Gain-of-function mutations in genes encoding the beta or gamma subunit of the ENaC channel. Diagnosis Low renin and aldosterone levels in the blood, [\u2026]<\/p>","protected":false},"author":1,"featured_media":0,"menu_order":0,"template":"","format":"standard","meta":{"_acf_changed":false,"slim_seo":{"title":"Liddle Syndrome - Kahramanmara\u015f S\u00fct\u00e7\u00fc \u0130mam University Health Practice and Research Hospital","description":"Definition: Liddle syndrome is a disorder resulting from overactivity of the epithelial sodium channel (ENaC) in the distal nephron, characterized by hypertension and low renin\/aldosterone levels."},"footnotes":""},"class_list":["post-21322","hastaliklar","type-hastaliklar","status-publish","format-standard","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/hastaliklar\/21322","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/hastaliklar"}],"about":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/types\/hastaliklar"}],"author":[{"embeddable":true,"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":0,"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/hastaliklar\/21322\/revisions"}],"wp:attachment":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/media?parent=21322"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}