{"id":21319,"date":"2025-11-17T01:45:45","date_gmt":"2025-11-16T22:45:45","guid":{"rendered":"https:\/\/hastane.ksu.edu.tr\/hastaliklar\/konjenital-adrenal-hiperplazi\/"},"modified":"2025-11-17T01:45:45","modified_gmt":"2025-11-16T22:45:45","slug":"konjenital-adrenal-hiperplazi","status":"publish","type":"hastaliklar","link":"https:\/\/hastane.ksu.edu.tr\/en\/hastaliklar\/konjenital-adrenal-hiperplazi\/","title":{"rendered":"Congenital Adrenal Hyperplasia"},"content":{"rendered":"<h2>Definition<\/h2>\n<p>Congenital adrenal hyperplasia is a group of autosomal recessive hereditary diseases resulting from enzyme deficiencies in the adrenal steroidogenesis pathways. 21-hydroxylase deficiency is the most common.<\/p>\n<h2>Symptoms<\/h2>\n<ul>\n<li>Ambiguous genitalia in girls<\/li>\n<li>Salt loss crisis (vomiting, dehydration)<\/li>\n<li>Early puberty<\/li>\n<li>Short stature<\/li>\n<\/ul>\n<h2>Reasons<\/h2>\n<p>Mutations in steroidogenesis enzyme genes (CYP21A2 most common).<\/p>\n<h2>Diagnosis<\/h2>\n<p>Newborn screening, elevated 17-hydroxyprogesterone in the blood.<\/p>\n<h2>Treatment<\/h2>\n<p>Cortisol replacement, mineralocorticoid replacement (if salt loss is present).<\/p>\n<h2>Which Polyclinic Should You Apply To?<\/h2>\n<p><strong>Pediatric Endocrinology Polyclinic<\/strong><\/p>\n<h2>What to Do in an Emergency?<\/h2>\n<p>In case of adrenal crisis (vomiting, diarrhea, hypotension, shock), emergency services should be consulted immediately.<\/p>\n<p><em>This page is for general information purposes only.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Definition: Congenital adrenal hyperplasia is a group of autosomal recessive inherited diseases resulting from enzyme deficiencies in the adrenal steroidogenesis pathways. 21-hydroxylase deficiency is the most common. Symptoms: Ambiguous genitalia in girls, salt-losing crisis (vomiting, dehydration), early puberty, short stature. Causes: Mutations in steroidogenesis enzyme genes (CYP21A2 most common). Diagnosis: Newborn screening, high levels of 17-hydroxyprogesterone in blood. Treatment: Cortisol replacement, mineralocorticoids [\u2026]<\/p>","protected":false},"author":1,"featured_media":0,"menu_order":0,"template":"","format":"standard","meta":{"_acf_changed":false,"slim_seo":{"title":"Congenital Adrenal Hyperplasia - Kahramanmara\u015f S\u00fct\u00e7\u00fc \u0130mam University Health Practice and Research Hospital","description":"Definition: Congenital adrenal hyperplasia is a group of autosomal recessive inherited diseases resulting from enzyme deficiencies in the adrenal steroidogenesis pathways."},"footnotes":""},"class_list":["post-21319","hastaliklar","type-hastaliklar","status-publish","format-standard","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/hastaliklar\/21319","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/hastaliklar"}],"about":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/types\/hastaliklar"}],"author":[{"embeddable":true,"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":0,"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/hastaliklar\/21319\/revisions"}],"wp:attachment":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/media?parent=21319"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}