{"id":21284,"date":"2025-11-17T01:45:44","date_gmt":"2025-11-16T22:45:44","guid":{"rendered":"https:\/\/hastane.ksu.edu.tr\/hastaliklar\/alkaptonuri\/"},"modified":"2025-11-17T01:45:44","modified_gmt":"2025-11-16T22:45:44","slug":"alkaptonuri","status":"publish","type":"hastaliklar","link":"https:\/\/hastane.ksu.edu.tr\/en\/hastaliklar\/alkaptonuri\/","title":{"rendered":"Alkaptonuria"},"content":{"rendered":"<h2>Definition<\/h2>\n<p>Alkaptonuria is a metabolic disease characterized by homogentisate dioxygenase enzyme deficiency, darkening of the urine on contact with air and ochronosis.<\/p>\n<h2>Symptoms<\/h2>\n<ul>\n<li>Darkening of urine<\/li>\n<li>Ochronosis<\/li>\n<li>Arthritis<\/li>\n<li>Cardiac valve involvement<\/li>\n<\/ul>\n<h2>Reasons<\/h2>\n<p>HGD gene mutation.<\/p>\n<h2>Diagnosis<\/h2>\n<p>Urine homogentisic acid, genetic testing.<\/p>\n<h2>Treatment<\/h2>\n<p>Nitisinone, symptomatic treatment.<\/p>\n<h2>Which Polyclinic Should You Apply To?<\/h2>\n<p><strong>Metabolism Polyclinic<\/strong><\/p>\n<h2>What to Do in an Emergency?<\/h2>\n<p>In case of acute arthritis attacks, emergency services should be consulted.<\/p>\n<p><em>This page is for general information purposes only.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Definition: Alkaptonuria is a metabolic disease characterized by homogentisticate dioxygenase enzyme deficiency, resulting in darkening of the urine upon contact with air and ochronosis. Symptoms: Darkening of urine, Ochronosis, Arthritis, Cardiac valve involvement. Causes: HGD gene mutation. Diagnosis: Urinary homogentistic acid test, genetic testing. Treatment: Nitisinone, symptomatic treatment. Which Clinic Should You Visit? Metabolism Clinic. What to Do in an Emergency? In case of acute arthritis attacks [\u2026]<\/p>","protected":false},"author":1,"featured_media":0,"menu_order":0,"template":"","format":"standard","meta":{"_acf_changed":false,"slim_seo":{"title":"Alkaptonuria - Kahramanmara\u015f S\u00fct\u00e7\u00fc \u0130mam University Health Practice and Research Hospital","description":"Definition: Alkaptonuria is a metabolic disease characterized by homogenate dioxygenase enzyme deficiency, resulting in darkening of the urine upon contact with air and ochronosis."},"footnotes":""},"class_list":["post-21284","hastaliklar","type-hastaliklar","status-publish","format-standard","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/hastaliklar\/21284","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/hastaliklar"}],"about":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/types\/hastaliklar"}],"author":[{"embeddable":true,"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":0,"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/hastaliklar\/21284\/revisions"}],"wp:attachment":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/media?parent=21284"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}