{"id":21264,"date":"2025-11-17T01:45:43","date_gmt":"2025-11-16T22:45:43","guid":{"rendered":"https:\/\/hastane.ksu.edu.tr\/hastaliklar\/piruvat-dehidrogenaz\/"},"modified":"2025-11-17T01:45:43","modified_gmt":"2025-11-16T22:45:43","slug":"piruvat-dehidrogenaz","status":"publish","type":"hastaliklar","link":"https:\/\/hastane.ksu.edu.tr\/en\/hastaliklar\/piruvat-dehidrogenaz\/","title":{"rendered":"Pyruvate Dehydrogenase Deficiency"},"content":{"rendered":"<h2>Definition<\/h2>\n<p>Pyruvate dehydrogenase deficiency is a metabolic disease characterized by pyruvate metabolism disorder, lactic acidosis, and neurological disorders.<\/p>\n<h2>Symptoms<\/h2>\n<ul>\n<li>Lactic acidosis<\/li>\n<li>Neurological decline<\/li>\n<li>Hypotonia<\/li>\n<li>Convulsions<\/li>\n<\/ul>\n<h2>Reasons<\/h2>\n<p>PDHA1 and other gene mutations.<\/p>\n<h2>Diagnosis<\/h2>\n<p>Enzyme activity, genetic testing.<\/p>\n<h2>Treatment<\/h2>\n<p>Ketogenic diet, thiamine.<\/p>\n<h2>Which Polyclinic Should You Apply To?<\/h2>\n<p><strong>Metabolism Polyclinic<\/strong><\/p>\n<h2>What to Do in an Emergency?<\/h2>\n<p>In case of metabolic acidosis, emergency services should be consulted.<\/p>\n<p><em>This page is for general information purposes only.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Definition: Pyruvate dehydrogenase deficiency is a metabolic disease characterized by impaired pyruvate metabolism, resulting in lactic acidosis and neurological impairment. Symptoms: Lactic acidosis, neurological regression, hypotonia, seizures. Causes: PDHA1 and other gene mutations. Diagnosis: Enzyme activity, genetic testing. Treatment: Ketogenic diet, thiamine. Which Clinic Should You Go To? Metabolism Clinic. What to Do in an Emergency? In case of metabolic acidosis, go to the emergency room [\u2026]<\/p>","protected":false},"author":1,"featured_media":0,"menu_order":0,"template":"","format":"standard","meta":{"_acf_changed":false,"slim_seo":{"title":"Pyruvate Dehydrogenase Deficiency - Kahramanmara\u015f S\u00fct\u00e7\u00fc \u0130mam University Health Practice and Research Hospital","description":"Definition: Pyruvate dehydrogenase deficiency is a metabolic disorder characterized by impaired pyruvate metabolism, resulting in lactic acidosis and neurological impairment."},"footnotes":""},"class_list":["post-21264","hastaliklar","type-hastaliklar","status-publish","format-standard","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/hastaliklar\/21264","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/hastaliklar"}],"about":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/types\/hastaliklar"}],"author":[{"embeddable":true,"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":0,"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/hastaliklar\/21264\/revisions"}],"wp:attachment":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/media?parent=21264"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}