{"id":21239,"date":"2025-11-17T01:45:43","date_gmt":"2025-11-16T22:45:43","guid":{"rendered":"https:\/\/hastane.ksu.edu.tr\/hastaliklar\/hurler\/"},"modified":"2025-11-17T01:45:43","modified_gmt":"2025-11-16T22:45:43","slug":"hurler","status":"publish","type":"hastaliklar","link":"https:\/\/hastane.ksu.edu.tr\/en\/hastaliklar\/hurler\/","title":{"rendered":"Mucopolysaccharidosis Type I (Hurler Syndrome)"},"content":{"rendered":"<h2>Definition<\/h2>\n<p>Mucopolysaccharidosis type I is a lysosomal storage disease characterized by coarse facial appearance, skeletal anomalies, and progressive neurological impairment, resulting from alpha-L-iduronidase enzyme deficiency.<\/p>\n<h2>Symptoms<\/h2>\n<ul>\n<li>Rough facial appearance<\/li>\n<li>Skeletal anomalies<\/li>\n<li>Hepatosplenomegaly<\/li>\n<li>Corneal opacity<\/li>\n<\/ul>\n<h2>Reasons<\/h2>\n<p>IDUA gene mutation.<\/p>\n<h2>Diagnosis<\/h2>\n<p>Urine GAG, enzyme activity.<\/p>\n<h2>Treatment<\/h2>\n<p>Enzyme replacement therapy, bone marrow transplantation.<\/p>\n<h2>Which Polyclinic Should You Apply To?<\/h2>\n<p><strong>Metabolism Polyclinic<\/strong><\/p>\n<h2>What to Do in an Emergency?<\/h2>\n<p>In case of respiratory distress, emergency services should be consulted.<\/p>\n<p><em>This page is for general information purposes only.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Definition: Mucopolysaccharidosis type I is a lysosomal storage disease resulting from alpha-L-iduronidase enzyme deficiency, characterized by coarse facial features, skeletal anomalies, and progressive neurological impairment. Symptoms: Coarse facial features, skeletal anomalies, hepatosplenomegaly, corneal opacity. Causes: IDUA gene mutation. Diagnosis: Urinary GAG, enzyme activity. Treatment: Enzyme replacement therapy, bone marrow transplantation. Which Clinic to Visit? Metabolism Clinic. Emergency [\u2026]<\/p>","protected":false},"author":1,"featured_media":0,"menu_order":0,"template":"","format":"standard","meta":{"_acf_changed":false,"slim_seo":{"title":"Mucopolysaccharidosis Type I (Hurler Syndrome) - Kahramanmara\u015f S\u00fct\u00e7\u00fc \u0130mam University Health Practice and Research Hospital","description":"Definition: Mucopolysaccharidosis type I is a disorder resulting from alpha-L-iduronidase enzyme deficiency, characterized by coarse facial features, skeletal abnormalities, and progressive neurological impairment."},"footnotes":""},"class_list":["post-21239","hastaliklar","type-hastaliklar","status-publish","format-standard","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/hastaliklar\/21239","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/hastaliklar"}],"about":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/types\/hastaliklar"}],"author":[{"embeddable":true,"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":0,"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/hastaliklar\/21239\/revisions"}],"wp:attachment":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/media?parent=21239"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}