{"id":21153,"date":"2025-11-17T01:45:45","date_gmt":"2025-11-16T22:45:45","guid":{"rendered":"https:\/\/hastane.ksu.edu.tr\/hastaliklar\/mccune-albright\/"},"modified":"2025-11-17T01:45:45","modified_gmt":"2025-11-16T22:45:45","slug":"mccune-albright","status":"publish","type":"hastaliklar","link":"https:\/\/hastane.ksu.edu.tr\/en\/hastaliklar\/mccune-albright\/","title":{"rendered":"McCune-Albright Syndrome"},"content":{"rendered":"<h2>Definition<\/h2>\n<p>McCune-Albright syndrome is a disorder caused by a somatic mutation in the GNAS gene, characterized by fibrous dysplasia of bone, caf\u00e9-au-lait spots, and endocrine overfunction.<\/p>\n<h2>Symptoms<\/h2>\n<ul>\n<li>Polycystic fibrous dysplasia (bone pain, deformity)<\/li>\n<li>Caf\u00e9-au-lait stains (coffee with milk color)<\/li>\n<li>Endocrine hyperfunction (precocious puberty, hyperthyroidism)<\/li>\n<li>Short stature<\/li>\n<\/ul>\n<h2>Reasons<\/h2>\n<p>Somatic (postzygotic) activating mutation in the GNAS gene.<\/p>\n<h2>Diagnosis<\/h2>\n<p>Clinical triad, bone X-ray, hormone tests.<\/p>\n<h2>Treatment<\/h2>\n<p>Symptomatic treatment (painkillers, bisphosphonates), treatment of endocrine problems.<\/p>\n<h2>Which Polyclinic Should You Apply To?<\/h2>\n<p><strong>Endocrinology Polyclinic<\/strong> or <strong>Orthopedic Polyclinic<\/strong><\/p>\n<h2>What to Do in an Emergency?<\/h2>\n<p>In case of pathological fracture or severe pain, emergency services should be consulted.<\/p>\n<p><em>This page is for general information purposes only.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Definition McCune-Albright syndrome is a disease characterized by fibrous dysplasia of the bone, caf\u00e9-au-lait spots, and endocrine overfunction, caused by a somatic mutation in the GNAS gene. Symptoms Polycystic fibrous dysplasia (bone pain, deformity) Caf\u00e9-au-lait spots (milk coffee color) Endocrine overfunction (precocious puberty, hyperthyroidism) Short stature Causes Somatic (postzygotic) activating mutation in the GNAS gene. Diagnosis Clinical triad, bone radiography, [\u2026]<\/p>","protected":false},"author":1,"featured_media":0,"menu_order":0,"template":"","format":"standard","meta":{"_acf_changed":false,"slim_seo":{"title":"McCune-Albright Syndrome - Kahramanmara\u015f S\u00fct\u00e7\u00fc \u0130mam University Health Practice and Research Hospital","description":"Definition: McCune-Albright syndrome is characterized by fibrous dysplasia of the bone, caf\u00e9-au-lait spots, and endocrine overfunction, caused by a somatic mutation in the GNAS gene."},"footnotes":""},"class_list":["post-21153","hastaliklar","type-hastaliklar","status-publish","format-standard","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/hastaliklar\/21153","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/hastaliklar"}],"about":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/types\/hastaliklar"}],"author":[{"embeddable":true,"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":2,"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/hastaliklar\/21153\/revisions"}],"predecessor-version":[{"id":21326,"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/hastaliklar\/21153\/revisions\/21326"}],"wp:attachment":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/media?parent=21153"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}