{"id":21135,"date":"2025-11-17T01:45:45","date_gmt":"2025-11-16T22:45:45","guid":{"rendered":"https:\/\/hastane.ksu.edu.tr\/hastaliklar\/noonan\/"},"modified":"2025-11-17T01:45:45","modified_gmt":"2025-11-16T22:45:45","slug":"noonan-sendromu","status":"publish","type":"hastaliklar","link":"https:\/\/hastane.ksu.edu.tr\/en\/hastaliklar\/noonan-sendromu\/","title":{"rendered":"Noonan Syndrome"},"content":{"rendered":"<h2>Definition<\/h2>\n<p>Noonan syndrome is an autosomal dominant genetic syndrome characterized by congenital heart defects, short stature, characteristic facial appearance, and pterygium colli.<\/p>\n<h2>Symptoms<\/h2>\n<ul>\n<li>Congenital heart diseases such as pulmonary stenosis<\/li>\n<li>Short stature<\/li>\n<li>Hypertelorism, ptosis<\/li>\n<li>Developmental delay<\/li>\n<\/ul>\n<h2>Reasons<\/h2>\n<p>Gene mutations in the RAS\/MAPK signaling pathway (PTPN11, SOS1, RAF1).<\/p>\n<h2>Diagnosis<\/h2>\n<p>Clinical criteria, genetic testing.<\/p>\n<h2>Treatment<\/h2>\n<p>Growth hormone, surgical treatment of cardiac anomalies, supportive care.<\/p>\n<h2>Which Polyclinic Should You Apply To?<\/h2>\n<p><strong>Pediatric Cardiology Clinic<\/strong> or <strong>Genetics Polyclinic<\/strong><\/p>\n<h2>What to Do in an Emergency?<\/h2>\n<p>In case of symptoms of heart failure due to congenital heart disease, emergency services should be consulted.<\/p>\n<p><em>This page is for general information purposes only.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Definition Noonan syndrome is an autosomal dominant genetic syndrome characterized by congenital heart defects, short stature, characteristic facial features, and pterygium coli. Symptoms Congenital heart defects such as pulmonary stenosis Short stature Hypertelorism, ptosis Developmental delay Causes Gene mutations in the RAS\/MAPK signaling pathway (PTPN11, SOS1, RAF1). Diagnosis Clinical criteria, genetic testing. Treatment Growth hormone, surgical correction of cardiac anomalies [\u2026]<\/p>","protected":false},"author":1,"featured_media":0,"menu_order":0,"template":"","format":"standard","meta":{"_acf_changed":false,"slim_seo":{"title":"Noonan Syndrome - Kahramanmara\u015f S\u00fct\u00e7\u00fc \u0130mam University Health Practice and Research Hospital","description":"Definition: Noonan syndrome is an autosomal dominant genetic disorder characterized by congenital heart defects, short stature, characteristic facial features, and pterygium coli."},"footnotes":""},"class_list":["post-21135","hastaliklar","type-hastaliklar","status-publish","format-standard","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/hastaliklar\/21135","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/hastaliklar"}],"about":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/types\/hastaliklar"}],"author":[{"embeddable":true,"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":1,"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/hastaliklar\/21135\/revisions"}],"predecessor-version":[{"id":21338,"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/hastaliklar\/21135\/revisions\/21338"}],"wp:attachment":[{"href":"https:\/\/hastane.ksu.edu.tr\/en\/wp-json\/wp\/v2\/media?parent=21135"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}